Strobilurins are a group of chemical compounds used in agriculture as fungicides. They are part of the larger group of QoI inhibitors, which act to inhibit the respiratory chain at the level of Complex III.
Some common Strobilurins are azoxystrobin, kresoxim-methyl, picoxystrobin, fluoxastrobin, oryzastrobin, dimoxystrobin, pyraclostrobin and trifloxystrobin.
Strobilurins represented a major development in fungus-based fungicides. They were extracted from the fungus Strobilurus tenacellus. They have a suppressive effect on other fungi, reducing competition for nutrients; they inhibit electron transfer in mitochondria, disrupting energy metabolism and preventing growth of the target fungi.
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- Let GOI & CIB permit import/ manufacture/ formulation of QoI or Strobilurins; consider modification of labels
- Don’t get scared of resistance –Follow FRAC guidelines religiously and Relax
Discovery of Strobilurins
- Source of maiden fungicide: Strobilurus tenacellus
- Anke & Steglich (1977) identified strobilurin A – Antifungal antibiotic, but photolabile in nature
- Chemists modified to restore stability
- First synthetic with +UV stability in 1986 in cooperation with BASF
- 1992 ICI developed Azoxystrobin; and BASF Kresoxim-methyl
- 1996- Commercialization